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Donald M. Small, M.D.Professor of Physiology and Biophysics,
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ResearchLipoproteins and Disease
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Contact UsDepartment of Physiology and Biophysics
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Our interests cover the general area of the physical properties of fats and oils, detergents, lipids, proteins and lipid-protein interactions. Specific systems of interest include artificial membranes (bilayers), surfaces and cores of native lipoproteins, and recombinant lipoproteins using specific lipids and either native or genetically engineered apolipoproteins. A biophysical approach is used to probe disease processes such as athersclerosis, lipoproteinemias and gallstone formation. Recent work includes: (1) physical characterization of stereospecific lipids and fats, (2) the recombination of lipids with native or genetically engineered fragments of apolipoproteins to produce recombinant lipoproteins, (3) physical analysis of recombinant lipoprotein particles and (4) studies of the metabolism of recombinant lipoproteins in whole animals, perfused livers and cell cultures. The mechanisms of progression and regression of atherosclerosis are also being pursued. A wide variety of biophysical, biochemical and physiological methods are used to probe these problems.
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