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Jeffrey R. Moore, Ph.D.
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ResearchActin and myosin based motile systems are involved in a wide range of cellular motile functions ranging from muscle contraction to organelle transport. In all of these systems the mechanism through which myosin is able to produce force and generate movement is still poorly understood at a molecular level. To study myosin’s enzymatic mechanism in a defined system, we employ state-of-the-art laser trapping techniques and in vitro motility assays. Currently, our research focuses on the effects of specific amino acid substitutions on myosin’s mechanical and enzymatic properties. |
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PublicationsGreenberg, M., Wang, C-L., Lehman, W., Moore, J., (2007) Modulation of actin mechanics by caldesmon and tropomyosin. Cell Motility and Cytoskeleton. [Epub ahead of print] Szczesna-Cordary, D., Jones, M., Moore, J., Watt, J., Kerrick, G., Xu, Y., Wang, Y., Wagg, C., and Lopaschuk, G. (2007) Myosin Regulatory Light Chain E22K Mutation Results in Decreased Cardiac Intracellular Calcium and Force Transients. FASEB J. Debold, E., Schmitt, J., Moore, J., Patlak, J., Beck, S., Seidman, J., Seidman, C., Warshaw, D. (2007) Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse a-cardiac myosin in the laser trap assay. Moore, J., (2005) Stretch activation: Toward a molecular mechanism. in “Nature’s Versatile engine: Insect flight muscle Inside and Out”, Vigoreaux J., ed., Landes Bioscience Publishers. Moore, J., Krementsova, E., Trybus, K., Warshaw, D.,(2004) Is the myosin V neck a compliant lever?, J. Mus. Res. Cell Motil. 25(1):29-35. Irving T, Bhattacharya S, Tesic I, Moore, J., Farman, Simcox A, Vigoreaux J, Maughan D. (2001) Changes in myofibrillar structure and function produced by N-terminal deletion of the regulatory light chain in Drosophila. Submitted to J. Mus. Res. Cell Motil., 22(8):675-83. Moore, J., Krementsova E, Trybus K, Warshaw D. (2001) Myosin V exhibits a high duty cycle and large unitary displacement, J. Cell Biol.,155 (4): 625-635 . Moore, J., Dickinson M, Vigoreaux J, Maughan D. (2000) The Effect of removing the N-terminal extension of the Drosophila Myosin Regulatory Light Chain Upon Flight Ability and the Contractile Dynamics of Indirect Flight Muscle. Biophys J. 78: 1431-1440. Vigoreaux J, Moore, J., Maughan D. (2000) Role of the elastic protein projectin in stretch activation and work output of Drosophila flight muscles. in “Elastic Filaments of the Cell”, Pollack G. and Granzier H, eds., Kluwer Academic/Plenum Publishers Moore, J., Vigoreaux J, Maughan D. (1999) The Projectin mutant bentD/+ has reduced stretch activation and altered indirect flight muscle kinetics.J. Mus. Res. Cell Motil. 20: 797-806. Maughan D, Moore, J., Vigoreaux J, Barnes B, Mulieri LA. (1998) Work production and work absorption in muscle strips from vertebrate cardiac and insect flight muscle fibers. Adv Exp Med Biol., 453:471-80 Vigoreaux JO, Hernandez C, Moore, J., Ayer G, Maughan D. (1998) A genetic deficiency that spans the flightin gene of Drosophila melanogaster affects the ultrastructure and function of the flight muscles. J Exp Biol., 201 ( Pt 13):2033-44 Dickinson MH, Hyatt CJ, Lehmann FO, Moore, J., Reedy MC, Simcox A, Tohtong R, Vigoreaux JO, Yamashita H, Maughan DW. (1997) Phosphorylation-dependent power output of transgenic flies: an integrated study. Biophys J.. 73(6):3122-34 • To top |
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Department of Physiology and Biophysics
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