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Hwai-Chen Guo, Ph.D.Associate Professor
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ResearchProtein Crystallography and Molecular Functions
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Publications:Xu, Q.S., Kucera, R.B., Roberts, R.J., and Guo, H.-C. (2004).
An asymmetric complex of restriction endonuclease MspI on its
palindromic DNA recognition site. Structure 12, 1741-1747. Qian, X., Guan, C., and Guo, H.-C. (2003). A dual role for an
aspartic acid in glycosylasparaginase autoproteolysis. Structure
11, 997-1003 Wang, Y. and Guo, H.-C. (2003). Two-step dimerization for autoproteolysis
to activate glycosylasparaginase. J. Biol. Chem. 278, 3210-3219. O'Loughlin, T.J., Xu, Q., Kucera, R.B., Dorner, L.F., Sweeney,
S., Schildkraut, I., and Guo, H.-C. (2000). Crystallization and
preliminary X-ray diffraction analysis of MspI restriction endonuclease
in complex with its cognate DNA. Acta Crystallogr. D56, 1652-1655. Xu, Q., Buckley, D., Guan, C., and Guo, H.-C. (1999). Structural insights into
the mechanism of intramolecular proteolysis. Cell 98, 651-661. Cui, T., Liao, P.-H., Guan, C., and Guo, H.-C. (1999). Purification and crystallization
of precursors and autoprocessed enzymes of Flavobacterium glycosylasparaginase:
an N-terminal nucleophile hydrolase. Acta Crystallogr. D55, 1961-1964. Guo, H.-C., Xu, Q., Buckley, D., and Guan, C. (1998). Crystal structures of
Flavobacterium glycosylasparaginase: an N-terminal nucleophile hydrolase activated
by intramolecular proteolysis. J. Biol. Chem. 273, 20205-20212. Bouvier, M., Guo, H.-C., Smith, K.J., and Wiley, D.C. (1998). Crystal structures
of HLA-A*0201 complexed with antigenic peptides with either the amino- or carboxyl-terminal
group substituted by a methyl group. Proteins Struct. Funct. Genet. 33, 97-106. Guo, H.-C., Madden, D.R., Silver, M.L., Jardetzky, T.S., Gorga, J.C., Strominger,
J.L., and Wiley, D.C. (1993). Comparison of the P2 specificity pocket in three
human histocompatibility antigens: HLA-A*6801, HLA-A*0201 and HLA-B*2705. Proc.
Natl. Acad. Sci. USA 90, 8053-8057. Guo, H.-C., Jardetzky, T.S., Garrett, T.P.J., Lane, W.S., Strominger, J.L.,
and Wiley, D.C. (1992). Different length peptides bind to HLA-Aw68 similarly
at their ends but bulge out in the middle. Nature 360, 364-366. Silver, M.L., Guo, H.-C., Strominger, J.L., and Wiley, D.C. (1992). Atomic
structure of a human MHC molecule presenting an influenza virus peptide. Nature
360, 367-369. Guo, H.-C. and Roberts, J.W. (1990). Heterogeneous initiation due to slippage
at the bacteriophage 82 late gene promoter in vitro. Biochemistry 29, 10702-10709.
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Contact UsHwai-Chen Guo, Ph.D.
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The other research areas are structural studies of factors interacting with nucleic acids. These include transcription factors, regulatory proteins, as well as restriction enzymes with unique DNA cleavage patterns. The goal is to understand the structural basis for their functions, and (specific) interactions of protein-protein and protein-nucleic acid, at atomic resolution.
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